FREE Shipping On All Orders

Sorry, the Dental-Cool is currently unavailable, please call for product availability

Oral Cryotherapy Studies White Papers

Find out about the new, holistic, non-opioid method to treat oral pain effectively.

Learn How It Works

Oral Cryotherapy Studies

Use of Oral Cryotherapy and Ice in Dental Treatment


Cooling the mouth (oral cryotherapy) during and after dental treatments has been proved to be an effective strategy to manage post-operative oral pain and discomfort. Several research studies have reported the use of irrigation with cold fluids (with saline being commonly used) for reducing pain (as an anesthetic) during dental procedures for treating periodontitis, in root canal treatment, and in molar surgery. In addition, oral inflammatory conditions such as hyperplasia can also be treated with oral cryotherapy. Further, cooling the teeth and root surfaces has been shown to result in significant reduction in pain and bacterial infection. An interesting utility of oral cooling in improving taste and appetite has also been reported, specifically in a condition known as dysgeusia.

The use of ice cubes, ice popsicles, iced cotton buds, and ice packs has been reported in dental applications, in addition to cooling using liquid nitrogen, nitrous oxide, and refrigerants.


Pain and discomfort is a major problem in dental treatments including tooth extraction, debridement, surgery, and root canal treatment. Consequently, patient compliance and recovery are significantly affected.

The use of anesthetic, analgesic, and anti-inflammatory drugs has been done conventionally to address dental and oral pain and inflammation. Cooling of the mouth, teeth, and gums has also been reported as an alternative strategy for managing dental pain.

The earliest reports of cooling the mouth using ice to manage oral and dental pain can be traced back to the late 1980s.

This report summarizes all existing information of the use of cooling methods including ice as a form of anesthesia and as treatment for specific oral and dental conditions. The information is classified based on the source, consisting of research articles, medical reviews, clinical trial data, patent records, product information, and other non-technical literature such as magazine articles or other web-based media. Information sources are cited and included in the report with hyperlinks wherever possible. All downloaded literature has been collated.

Clinical Trials


Research Articles

The first available report of oral cryotherapy is the use of ice to ease toothache, published in 1988.

In the last decade, several individual research studies have reported the benefits of oral cryotherapy in treating dental conditions.